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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

These include nausea, diarrhea, vomiting, constipation, and abdominal discomfort

If the starting amount of muscle mass you have is the same or greater than what you had before you started, then you haven't lost muscle mass

A further consideration for women using tirzepatide (and potentially other incretin therapies) is the possible reduction in exposure to oral contraceptives, particularly around initiation and dose escalation

This means Ozempic users need to keep taking Ozempic indefinitely, especially if they want to retain a certain body type