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Testing first avoids blind supplementation and guides the right dose

Such multimodal combinations not only leverage mechanistic complementarity to enhance efficacy, but also reduce toxicity and delay relapse, yielding a more durable and controllable therapeutic response

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Importantly, Gokhale et al

The severity and duration of deficiency are primary determinantspatients with mild, recently developed deficiency typically respond more rapidly than those with longstanding, severe depletion