Juraszek and Nalecz, 2019)
Notably, a study involving approximately 276,000 participants from the UK Biobank cohort revealed that permanent night shift work, a condition acknowledged to reduce 24-hour melatonin levels [41], was associated with a 1.5-fold higher risk of developing AD during a median follow-up of 9 years [42]
Such symptoms have resulted from the over-stimulation of the thyroid due to the induction of hyperthyroidism through exogenous thyroid hormones and in turn cause excessive secretion of thyroid hormones, which disturb the feedback loop of the hypothalamic-pituitary-thyroid axis (Bao et al
Moreover, the peroxisome proliferator-activated receptor (PPAR) regulates OCTN2 expression by binding to the PPAR-response element within the first intron (Qu et al., 2014)
This makes them a convenient option for those with busy schedules or who do not want to take time off work or other activities