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Myers RD, Borg S, Mossberg R
10.1111/jcmm.13333 24 KillgoreJ.SmidtC.DuichL.Romero-ChapmanN.TinkerD.ReiserK.et al (1989)
Otherwise (less than three non-missing values), the slope for the peptide in question for an individual was set as missing (not available, NA)
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The Injection (Subcutaneous) - Dosing: Once weekly - Bioavailability: ~100% (bypasses GI tract) - Weight loss in trials: Up to 22% at 36 weeks - Best for: Patients seeking maximum efficacy, comfortable with self-injection The Pill (Oral) - Dosing: Once daily (taken on an empty stomach, similar to Rybelsus) - Bioavailability: Lower than SC (relies on SNAC absorption technology) - Weight loss in trials: Up to 13.1% at 12 weeks (Phase 1 short duration) - Best for: Injection-averse patients, early treatment, maintenance, broader access The oral formulation will almost certainly deliver less weight loss than the subcutaneous version at equivalent treatment durations
