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Kitzman DW, Nicklas BJ (2018) Pivotal Role of Excess Intra-Abdominal Adipose in the Pathogenesis of Metabolic/Obese HFpEF

Bile is good at doing that, but once its completed its job, it stays in the tract, reaching the far end of the intestine, where it stimulates GLP-1 secretion

In other studies, Mounjaro helped people lose 12 to 15 pounds on a 5-mg weekly dose, between 15 and 21 pounds on a 10-mg weekly dose, and between 17 and 25 pounds on a 15-mg weekly dose

Studies indicate that GLP-1RAs decrease major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) as well as in obese/overweight patients with cardiovascular disease

Some data from clinical trials indicate sustained changes in weight and metabolic markers