However, under some circumstances, oxalate may bind to minerals and form crystals that can lead to the formation of kidney stones ( Consuming too much vitamin C has the potential to increase the amount of oxalate in your urine, thus increasing your risk of developing kidney stones ( In one study, when adults took a 1,000-mg vitamin C supplement twice daily for 6 days, the amount of oxalate they excreted increased by 20% ( High vitamin C intake is not only associated with greater amounts of urinary oxalate but also linked to the development of kidney stones, especially if you consume more than 2,000 mg per day ( Instances of kidney failure have also been reported in people who have taken more than 2,000 mg in a day
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To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig
Pediatr Nephrol 41 , 277296 (2026)