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Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Clin Plasma Med , 9 , 613
A 2026 randomized trial published in JAMA Network Open found that berberine (1 gram daily for 6 months) did not reduce body fat in people with obesity, though it did lower LDL cholesterol and inflammation
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Metabolic effects of a carnitine-free diet fed to college students
Jensen SBK, Srensen V, Sandsdal RM, et al
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