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Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level
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17: 5660 Brass EP, Hoppel CL, Hiatt WR
Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB
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