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Treated animals achieved body composition parameters comparable to lean control groups

Those are two different kinds of evidence, and neither establishes that one route produces greater systemic exposure in a living organism

Inhibiting the enzyme is therefore investigated as a route to preserving both methyl donor pools and NAD+ availability, with downstream effects on sirtuin-dependent signaling

Difficulty concentrating and impaired memory: These may indicate a Vitamin B12 deficiency, which can also lead to mental health issues like depression and behavioral changes