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A broader review of the peptides relationship to the nitric oxide system describes its competing interactions with both L-arginine and L-arginine analogues across a range of experimental models [2]

It might not have anything to do with how much you move or how hot it is

Nucleic Acids Res 51 , 25292573 (2023)

Siegenthaler PA, Packer L (1965) Light-dependent volume changes and reactions in chloroplasts

However, as reassuring as all of this is, there are a couple of things to remain mindful of: Copper toxicity Because GHK-Cu contains copper, it does pose a potential risk of copper toxicity,12 the symptoms of which include abdominal pain, vomiting, chest pain, chills, cough, fever, general weakness, anemia, burning sensations, tremors, and a metallic taste in the mouth.13 The risk is small, as the concentrations of copper in the peptide are typically well within safe parameters, but its good to be aware of it