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However, while our results corroborate the existence of GLP-1R-associated endosomal signalling, they also suggest that sustained GLP-1R signalling, as indicated by cumulative insulin secretion over pharmacologically relevant timescales, is actually greater with the ligand (exendin-4-C16) with a reduced tendency to recruit mini-G s to Rab5-positive endosomes
The new phase 3 readout showed 20.8% in TRIUMPH-2 and 22.6% in TRIUMPH-3 at 80 weeks
38 LuY.YuanZ.ChenJ.WangZ.LiuZ.WuY.et al
For Retatrutide, those are GLP-1, GIP, and glucagon
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