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Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
This microbial shift disrupts multiple gutbrain pathways simultaneously: these shifts coincided with gut barrier disruption (elevated serum endotoxin), triggering elevated hippocampal cytokines (IL-6, TNF-), which in turn suppress Tph2 expression and induce Tph2 hypermethylation (suggesting neuroinflammation and serotonergic suppression), ultimately manifesting as anxiety and depression-like behaviors (Buchenauer et al., 2023)
Sies, H
It can be a slow process to uncover the cause
Gluten free Vegan Supplement Facts 30 Servings Serving Size: Six (6) Pumps Serving Per Container: 30 * Percent Daily Values are based on a 2,000 calorie diet
