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Moos WH, Faller DV, Glavas IP, Harpp DN, Kanara I, Mavrakis AN, Pernokas J, Pernokas M, Pinkert CA, Powers WR, Sampani K, Steliou K, Vavvas DG, Zamboni RJ, Kodukula K, Chen X (2020) Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs
Yes, Rybelsus does not require gradual dose reduction from a pharmacological perspective and does not cause withdrawal symptoms
It demonstrates that the GLP-1 receptor's activation pathway is "convergent" rather than "pathway-specific": multiple distinct binding events at the extracellular surface can trigger the same conformational rearrangement at the intracellular surface
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Int J Biol Macromol 280:135757
