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However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)
Clearly the brain/central nervous system effect of these drugs is gaining traction and considerable interest
"These risks highlight the importance of informed prescribing and appropriate monitoring, as well as the need for more data on their real-world safety and effectiveness. This study was funded by the Heart Foundation and the NHMRC Medicines Intelligence Centre of Research Excellence.
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