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It works through norepinephrine and dopamine reuptake inhibition rather than serotonin, which gives it a different metabolic profile
Do not start, adjust, or discontinue any GLP-1 therapy without consulting your healthcare provider
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Those taking insulin or sulfonylureas should be particularly vigilant for hypoglycaemia if their food intake is reduced due to illness or GI symptoms
In the latest episode of the Beyond Journal Club podcast from Core IM and NEJM Group, the hosts unpack the evolving language of steatotic liver disease and discuss two major trials: MAESTRO-NASH studying resmetirom, the first FDA-approved liver-directed therapy for MASH, and ESSENCE, evaluating semaglutide in biopsy-confirmed disease
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