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In experimental models, suppression of spermatogenesis in the testes and degeneration of primordial follicles and granulosa cells in the ovaries are considered hallmark features of platinum-induced gonadotoxicity.8 Chemotherapeutic agents have been shown to deplete intracellular Glutathione (GSH), one of the major endogenous antioxidants, while simultaneously increasing Myeloperoxidase (MPO) activity, an indicator of inflammatory response, and elevating Malondialdehyde (MDA), a marker of lipid peroxidation.9 Co-administration of antioxidants during chemotherapy has therefore been proposed as a strategy to mitigate oxidative stress-induced tissue injury and improve therapeutic tolerance
Clinics in Dermatology, 28, 412-419
Cyanocobalamin can also be prescribed to treat pernicious anemia, a condition where the body is unable to absorb sufficient amounts of vitamin B12 from food
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This often presents as a red, slightly raised, or itchy welt, sometimes called a "histamine reaction." Ipamorelin, in particular, can sometimes cause this localized release of histamine
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