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Retatrutide adds GIPR agonism (which augments insulin secretion and modulates central appetite circuits independently) and GCGR agonism (which increases energy expenditure and hepatic fat mobilisation)
Most people find that retatrutide appetite suppression at 4mg equals what they experienced at roughly 7.5 to 10mg tirzepatide
Weight loss generally improves liver health, and monitoring liver enzymes can document this improvement
Youll likely notice increased hunger within a week as the appetite-suppressing effects wear off
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