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In the 2026 ADA Scientific Sessions, results from the Phase-3 TRANSCEND-T2D-1 study involving retatrutide, a triple agonist of GLP-1, GIP, and glucagon receptors, showed up to a 2% decrease in A1C and a 16.8% decrease in body weight over 40 weeks in patients with type 2 diabetes

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Or maybe semaglutide could serve as a therapeutic but not enough of the drug slipped into patients brains to make a difference