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Dectin-1 activation by particulate - glucans was shown to promote the production of pro-inflammatory cytokines IL-6, IL-8, and TNF- in THP-1 macrophages via co-binding with TLR2 and TLR4 (184), as also shown in Figure 4

Whereas, L-Carnitine is found in animal products such as meat, fish, poultry and dairy

In the anaerobic pathway, PA is metabolized to benzoate by decarboxylation 38,39 , which is then transformed to acetate by -oxidation 40

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Electron microscopy MIN6B1-SNAP-GLP-1R cells cultured on Thermanox coverslips (Agar Scientific) were labeled with 2 M cleavable SNAP-Surface biotin probe in HEPES-bicarbonate buffer plus 3 mM glucose and 1% BSA, followed by incubation with 5 g ml 1 NaN 3 -free Alexa Fluor 488 Streptavidin, 10 nm colloidal gold conjugate (Molecular Probes) and stimulation with 100 nM agonist in buffer plus 11 mM glucose