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This is because B12 acts on the bone marrow to normalize red blood cell creation, and the life cycle of a red blood cell is 90 days
Peak levels can be delayed by 18 hours Volume of distribution is 0.1 0.2 L/kg Highly protein bound It is metabolised in the liver to multiple active metabolites Resuscitation: Attention to ABC: The need for intubation should be anticipated and performed early in anyone with a declining GCS
Risk factors for Korsakoffs syndrome include repetitive thiamine deficiency episodes and genetic predispositions, such as mutations in the transketolase enzyme that reduce its affinity for TPP (5)
