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In Eli Lillys clinical pharmacology data submitted to the FDA, a single 5 mg dose of tirzepatide reduced the maximum concentration of a birth control pill by roughly half and reduced overall exposure by about 20%

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This type of drug interaction may also reduce the rate of generation of toxic substrate

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After centrifuging at 13,000 rpm for 10 min at 4 C, the supernatant was removed and dried with nitrogen

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doi: 10.7326/M14-2385 10 BalduzziSRckerGNikolakopoulouAPapakonstantinouTSalantiGEfthimiouOet al

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