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Lowers a signaling protein (TGF-1) and reduces cell stress (measured by an antioxidant enzyme called SOD), both of which contribute to hair follicles shrinking due to the hormone DHT

276 Tirzepatide is associated with significantly greater proportion of achieving MASH remission with no worsening of fibrosis compared with placebo 277 in a phase 2 trial, and another phase 2 trial for dual agonism of glucagon receptor and GLP-1R (GCGR/GLP-1RA) survodutide demonstrated similar improvements in MASH

Mol Neurobiol 35:203216 Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM (2015) Neuronal-targeted TFEB accelerates lysosomal degradation of app, reducing A generation and amyloid plaque pathogenesis

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PMID 28323299