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Persistent diarrhea lasting more than two weeks, severe abdominal pain, or signs of dehydration, all of which the article says warrant immediate reporting

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Int Immunopharmacol 115:109647 Saffari PM, Alijanpour S, Takzaree N, Sahebgharani M, Etemad-Moghadam A, Noorbakhsh F, Partoazar A (2020) Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimers disease model

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