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A decrease in pup survival was seen at all doses
Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]
Dose escalation, which is standard practice with most GLP-1 medications, helps to optimise therapeutic effects whilst minimising gastrointestinal side effects
Plasma half-life is about 159-195 hours, or roughly 6.6-8.1 days
While murine models suggest atrial GLP-1R expression, the precise cardiac cell types expressing GLP-1R, especially in humans, are yet to be conclusively identified [33]
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