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[cited 2024 Feb 13]
The scaffold is a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, with norleucine at position 4 in place of the oxidation-prone methionine of the native hormone and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core
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The patients lost on average 43 pounds that was sustained at one year
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