These dual metabolic interactions make NNMT a uniquely positioned research target
Cancer , 111 , 1526-1531, doi: Corti, A., Franzini, M., Paolicchi, A., and Pompella, A
Butyrate can reduce tumors through a variety of mechanisms, including apoptosis induction, epigenetic alteration in gene expression, reduction of cell proliferation, and manipulation of cytokine levels and inflammatory responses during in vitro studies (271, 272)
Animal research used weight-based dosing roughly in the range of 10 mcg per kg, which for a 80 kg human would be approximately 800 mcg per day, though extrapolation from rodent to human dose is not straightforward and this is not a clinical recommendation
For the research context the article is key for understanding why the amylin + GLP-1 combination makes mechanistic sense