Semaglutide: Charting New Horizons in GLP-1 Analogue Outcome Studies [PMID: 32880877] Laboratory literature summary: Semaglutide: Charting New Horizons in GLP-1 Analogue Outcome Studies
Heart Fail Rev Mancini SJ, Boyd D, Katwan OJ, Strembitska A, Almabrouk TA, Kennedy S, Palmer TM, Salt IP (2018) Canagliflozin inhibits interleukin-1-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms
A large JAMA Surgery study found that over 2 years, mean total costs were higher for GLP-1 receptor agonists than for metabolic/bariatric surgery: about $63,483 for GLP-1 therapy vs $51,794 for surgery
Even taken daily, oral semaglutide may still deliver less of the drug to your system than injectable versions (though the difference is slight)
Interestingly, theres some evidence that your body increases its production when youre dehydrated