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Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP

The MOTS-c analog CB4211 was well-tolerated in a Phase 1 trial with 85 participants and no serious adverse events

This endeavor represents more than incremental progress, marking a fundamental paradigm shift from discovery biology to design immunology or immune engineering while simultaneously redefining therapeutic possibilities by systematically exploring the complexity boundaries of living systems

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