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10.1007/s12264-013-1348-5 Neurosci

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However, these pharmacologic benefits are tempered by important trade-offs, including gastrointestinal side effects, treatment cost, and loss of lean mass, which may have long-term functional implications if not counteracted by concurrent resistance exercise ( Exercise and lifestyle interventions, while generally less potent for weight loss, provide unique and irreplaceable health benefits preserving skeletal muscle, improving cardiorespiratory fitness, enhancing psychological well-being, and lowering chronic disease risk ( Hybrid care models that integrate pharmacotherapy with behavioral support are emerging as the most promising framework for sustainable obesity and diabetes management ( Persistent challenges include the high cost and limited accessibility of GLP-1RAs, variable long-term adherence, and a lack of long-term data on sustainability, relapse rates, and overall health outcomes

By balancing the potential benefits and risks of treatment using evidence-based strategies, HCPs are well placed to help optimise the use of GLP-1 RAs in the management of obesity and overweight

[PubMed] [PMC] Hoyeck MP, Angela Ching ME, Basu L, van Allen K, Palaniyandi J, Perera I, Poleo-Giordani E, Hanson AA, Ghorbani P, Fullerton MD, Bruin JE (2024) The aryl hydrocarbon receptor in -cells mediates the effects of TCDD on glucose homeostasis in mice