Indicators of endothelial dysfunction, such as sICAM-1, tPA antigen, and PAI-1 levels and activity, are higher in individuals with Metabolic Syndrome (MetS) (67)
Yet, according to a set of intra-chain hydrogen bonding analysis of supplementary file 4452.pdb , it was found that two sets of hydrogen bond-like electrostatic interactions (Table 5) exist between the two positively charged side chains of Arg123 and Arg127, with donor-acceptor (D-A) distances at 3.23 and 3.19 and two ADH at 16.94 and 28.90, while a cutoff value of donor-acceptor (D-A) distance was defined as 3.0 [50], and a cutoff value of the angle formed by acceptor (A), donor (D) and hydrogen (H) ( ADH ) was defined as 30
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Popa-Wagner A, Mitran S, Sivanesan S, Chang E, Buga AM
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