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According to CMS billing guidance (Medicare Article A57755), the primary covered indications are pernicious anemia, documented cobalamin deficiency with laboratory evidence, and malabsorption syndromes that prevent adequate oral B12 absorption
The main agents currently approved by the EMA and/or FDA include exenatide (2005/2005), liraglutide (2009/2010), lixisenatide (2013/2016), dulaglutide (2014/2014), semaglutide (2017/2017
They often evaluate whether a medication like Ozempic is medically necessary and fits within their formulary guidelines for weight management
For patients requiring further glycaemic control, the dose can be increased to 2 mg once weekly after at least 4 weeks at the 1 mg dose
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