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The contribution of these metabolites was only detectable when cells were cultured under physiological conditions
This was because the FDA identified significant, unresolved patient safety risks, making the 19 peptides ineligible for routine compounding by traditional, 503A pharmacies
The lifespan effects may result from the combination of telomere maintenance (delaying cellular senescence) and melatonin restoration (improving antioxidant defense, immune function, and circadian regulation) rather than either mechanism alone
N Engl J Med 2021;385:50315.ArticlePubMed 54
Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E, et al
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