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Gallbladder problems , including gallstones, have also been associated with GLP-1 therapy, likely related to rapid weight loss and changes in bile composition
treating obesity and curtailing its most devastating long-term effects
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However, persistent nausea throughout the day, nausea that interferes with eating or daily activities, or nausea accompanied by frequent vomiting suggests the dose exceeds your current tolerance
In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)
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