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doi:10.1073/pnas.95.13.7379

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(8) Excess body weight increases the mechanical load on weight-bearing joints, accelerating cartilage wear and joint degeneration, and contributing to a pro-inflammatory state that further exacerbates joint damage

To make the immortalized LT2MR cell line used in the luciferase experiments (Fig 3D), LT2M cells were engineered to stably express RAS by retroviral infection with pMSCVHRAS V12 virus

Reduced Fat Storage: This peptide helps prevent the formation of new fat cells, supporting long-term weight management