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The answer depends entirely on how they are used

Gradual taper of dose The Approach For patients who want to find the lowest effective dose or to discontinue completely, a gradual taper means stepping the GLP-1 dose down in small, planned increments (typically using the same titration steps as initiation, but in reverse) to test whether benefit can be maintained with less medication or none at all

Watson K, Nasca C, Aasly L, McEwen B, Rasgon N (2018) Insulin resistance, an unmasked culprit in depressive disorders: promises for interventions

This new approach offers a potential dual benefit, particularly for patients at risk of both diabetes and cardiovascular disease

Its not like the guy whos on 28 nM is on too much or the guy whos on a level of eight is on too little because thats where his body is set to. Prof McLachlan You can think of it like height perfectly healthy men can be 165cm or 205 cm, its just where you sit on the reference range