Similar reductions in IL-1 and TNF- were also observed after administering other polyphenols, including gallic acid (GA) at 100 mg/kg, for 112 days [20], chlorogenic acid (CGA) (80 mg/kg, p.o., for 16 weeks) [23], sesamol (100 mg/kg, p.o., for 8 weeks and 0.05% w/v, in drinking water, for 10 weeks) [24, 36], Nano-Honokiol (20 mg/kg, p.o., for 17 weeks) [27], quercetin-3-O-glucuronide (Q3G) (50 mg/kg, p.o., for 4 weeks) [33], and blueberrymulberry extract (BME) (300 mg/kg, p.o., for 6 weeks) [40]
For patients with adequate food intake and no concerning symptoms, routine laboratory monitoring may not be necessary
NutroxSun (Clinically researched blend of rosemary and grapefruit extracts): This powerful UV protectant may reduce skin redness, sunburn, and other UV damage
While some individuals report improvements in symptoms, research is still developing, and peptides should generally be viewed as part of a broader arthritis management strategy
There is no good quality clinical evidence to suggest that a reduction in sulphotransferase activity affects paracetamol metabolism or increases the risk of paracetamol toxicity (see Table 1 in the supplementary data for a summary of the evidence and see Fig