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The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus
Furthermore, emerging evidence suggests that GLP-1RAs may modulate central insulin signaling and synaptic plasticity, pathways that are increasingly implicated in the pathophysiology of AD
Dual GLP-1/GIP receptor agonists, such as tirzepatide, simultaneously activate both receptors, thereby potentiating glycemic control, promoting weight loss, and ameliorating metabolic dysfunction
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