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Zhihong Y, Chen W, Qianqian Z, Lidan S, Qiang Z, Jing H, et al
In addition, the change of DNA methylation is rather different between early and late stage (294, 295)
Clinical trials report excellent tolerability
Approximately 20%-30% of individuals with MASLD progress to MASH, characterized by hepatocyte ballooning, lobular inflammation, and variable fibrosis, and 10%-20% of MASH patients develop advanced fibrosis (stages F3-F4) or cirrhosis over their lifetime [6,13]
It plays an important role in brain function, DNA synthesis, and red blood cell production
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