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The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles

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In addition, studying the impact of DPP-4 inhibitors in combination with GLP-1 and GIP receptor antagonists in our Gcg -null animals allowed us to determine the relative roles of these two incretin peptides

doi: 10.4172/2329-8847.1000166