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Appetite suppression remains effective, though some individuals report slight tolerance development
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Johnstone AM, Murison SD, Duncan JS, Rance KA, Speakman JR: Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine
Pregnant or breastfeeding women and anyone with active or suspected cancer should avoid use without medical clearance
No alcohol if taking insulin or sulfonylureas alongside retatrutide (for T2D patients): the hypoglycemia risk in this combination is the one area where avoidance is genuinely warranted
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