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This selectivity is both the appeal and the limitation
B12 injections are a common treatment prescribed by healthcare professionals for people with a vitamin B12 deficiency
As an alternative to THF, folinic acid (5-formyltetrahydrofolate) can also be converted into 5, 10-methylenetetrahydrofolate
Not all medications and nutrients are small enough to get absorbed or need breakdown via gastric enzymes for activation for the sublingual route, but whenever possible there is a benefit to using this route as it bypasses potential damage/absorption issues in the GI tract
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