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Since tirzepatide has been shown to induce medullary thyroid carcinoma in both in vivo rat models and in vitro studies, it is not recommended for use in patients with a history of medullary thyroid carcinoma or those with multiple endocrine neoplasia type 2 syndrome
While individual requirements vary based on factors like age, sex, activity level, and health status, most adults need a minimum of 1,200 calories daily for women and 1,500 for men to obtain adequate protein, vitamins, and minerals
ISBN 978-0-12-709859-3
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2,3 In REDEFINE 1, adverse events were mainly gastrointestinal, (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)
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