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(2016) Do glutathione levels decline in aging human brain

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Cerebrolysin has specific evidence in a diabetic neuropathy mouse model showing dose-dependent nerve fiber improvements

The severe form of this disorder is characterized by a number of unusual biochemical features

This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017