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268 AXL activation mediates both intrinsic and acquired resistance to targeted therapies (e.g., EGFR-TKIs in NSCLC, HER2 inhibitors in breast cancer), chemotherapy (e.g., cisplatin, gemcitabine), and antiangiogenic agents (e.g., bevacizumab)
Keep vials upright, protected from light (wrap in aluminum foil or use amber vials if available), and away from the freezer compartment
That concentration of authorship is a documented limitation of the evidence base and is factored into every assessment below
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