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Deficiency of vitamin B12 has been loosely associated with dementia and impaired cognitive functioning in elderly patients

In contrast, the thienotriazolopyrimidinone scaffold ( DNS-0056 ) shows superior oral bioavailability and CNS exposure, although substitutions at C-6/C-8/C-9 markedly affect MDR1 efflux (Dyck et al., 2017)

Ultimately, this mechanism achieves the goal of inhibiting vascular aging