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The ssGSEA R package was used to calculate four metabolic mode scores of each patient in indicated datasets based on corresponding metabolic gene-sets (Glycolysis, oxidative phosphorylation, fatty acid, and glutamine metabolism) downloaded from Gene Set Enrichment Analysis website (GSEA, (Supplementary Data 1)
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While more research is needed, other mood-boosting supplements may interact with antidepressants, too, according to 2023 research in Frontiers in Pharmacology
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