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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist
Structural changes help it bind more tightly to the GLP-1 receptor and resist breakdown, allowing once-weekly dosing instead of daily injections
Pharmacies that conduct their own rigorous stability testing may assign longer BUDs, sometimes up to 120 days
(PubMed) Cherchi A, Lai C, Angelino F, et al
Nausea and most gastrointestinal side effects typically resolve within 1-2 weeks as medication concentration drops, though some patients report mild digestive changes into week 3-4
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