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These individuals experience a decrease in the number of CD4+ T-cells, making them highly susceptible to MTB infection and reactivation of latent MTB infection (LTBI) ( + T cells contribute to protective immunity against MTB ( MTB -derived antigens to T cells, host immune cells such as macrophages and dendritic cells use major histocompatibility complex (MHC) molecules ( MTB infection

Moreover, KPV is also recognized as a natural antimicrobial peptide

Supplementary Material S4 details all exercise activities included in each study arm according to type (Aerobic, Resistance, Balance, Others), MET, number of sessions per week and minutes per session

| Mark Hyman, MD

10.1017/S0007114508939830 51 RiderS