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Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)
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Aberrant astrocytes cannot provide homoeostatic support, but instead generate reactive oxygen species that may mediate neurotoxicity
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