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While co-treatment with 300 nM Ex-4 during differentiation suppressed osteogenic marker expression of RUNX2 , bone morphogenetic protein 2 ( BMP2 ), ALP and matrix deposition, early exposure prior to differentiation start or at the time of cell isolation, enhanced osteogenic marker expression [15]

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Wang R, Lagakos SW, Ware JH, et al

This means, GST is added onto other proteins to create a GST-fusion protein that will help keep the protein of interest from precipitating

Generally, such a supplement is considered safe for most men and women